Sodium Caseinate Nanomicelles as a Novel Drug Delivery System for Doxorubicin

Event Abstract Back to Event Sodium caseinate nanomicelles as a novel drug delivery system for doxorubicin Farah Rehan1*, Manish Gupta1* and Nafees Ahemad1* 1 Monash University Malaysia, Malaysia Background Breast cancer is the most common cancer amongst women in both the developed and less developed world. It impacts over 1.5 million women worldwide each year. Doxorubicin (DOX) is a widely used drug for breast cancer. However, researchers are still looking for appropriate delivery system that can overcome acquired resistance and toxicity associated with DOX. Casein nanomicelles, the major fraction of milk protein, are emerging as a novel drug delivery system owing to their various structural and functional properties. Methods DOX was successfully loaded into sodium caseinate nanomicelles (NaCNs) which were formulated and optimised through magnetic stirring. Zeta size and zeta potential of formulations were measured and then formulations were further characterised through FESEM, TEM, FTIR and XRD. In-vitro drug release study was also assessed by using dialysis membrane. Results NaCNs yielded sizes that ranged from 348.8 nm (blank micelles) to 604 nm (drug-loaded micelles) and, negative zeta potential of -22.1 (blank micelles) to -21.9 mV (drug-loaded micelles). DOX showed significant encapsulation efficiency (71.57% ± 4.855) and drug loading (2.01±0.095). Morphological characterisation through FESEM and TEM revealed the spherical morphology of micelles of both unloaded and loaded micelles. XRD data confirmed the amorphous nature of the formulated drug-loaded micelles. FTIR spectra indicated the proper entrapment of the drug and confirmed no chemical interaction between the drug and the micelles. Drug release profile of the loaded micelles revealed that the colloidal drug carrier could release the drug in a slow manner under normal physiological conditions. Conclusion The present findings implied the potential of overcoming the limitations associated with DOX by formulating DOX-loaded NaCNs against breast cancer. Keywords: breast cancer, Nanomicelles, Doxorubicin, FESEM, Encapsulation efficiency Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Oral Presentation Topic: Cancer Citation: Rehan F, Gupta M and Ahemad N (2019). Sodium caseinate nanomicelles as a novel drug delivery system for doxorubicin. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00004 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2018; Published Online: 17 Jan 2019. * Correspondence: Ms. Farah Rehan, Monash University Malaysia, Bandar Sunway, Malaysia, farah.rehan@monash.edu Dr. Manish Gupta, Monash University Malaysia, Bandar Sunway, Malaysia, manugupta1@gmail.com Dr. Nafees Ahemad, Monash University Malaysia, Bandar Sunway, Malaysia, Nafees.Ahemad@monash.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Farah Rehan Manish Gupta Nafees Ahemad Google Farah Rehan Manish Gupta Nafees Ahemad Google Scholar Farah Rehan Manish Gupta Nafees Ahemad PubMed Farah Rehan Manish Gupta Nafees Ahemad Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.