光热治疗
生物相容性
光热效应
体内
PEG比率
化学
自愈水凝胶
细胞毒性
控制释放
黑磷
纳米技术
聚合物
药物输送
生物医学工程
材料科学
化学工程
体外
核化学
剂型
生物物理学
毒品携带者
高分子化学
有机化学
生物化学
医学
经济
生物技术
生物
光电子学
财务
作者
Rong-Si Wu,Juan Lin,Yanmei Xing,Zhongliang Dai,Liwei Wang,Xueping Zhang
标识
DOI:10.1016/j.xphs.2019.03.003
摘要
In this study, black phosphorus nanosheets (BPNSs) were incorporated into a hydrogel formed from dibenzaldehyde-functionalized polymer (DF-PEG) and polyaspartylhydrazide (PAHy) polymer to create an injectable and pH-sensitive DF-PEG-PAHy/BPNSs hydrogel, which can be used as a smart depot for synergistic chemo-photothermal cancer therapy. The DF-PEG-PAHy/BPNSs hydrogel exhibited excellent gelation characteristics, pH sensitivity, and near-infrared responsiveness. The nanocomposite hydrogel provided controlled drug release and near-infrared irradiation speeded up release of drug from the hydrogel because of the photothermal effect of the BPNSs. Cytotoxicity tests confirmed that the hydrogel has good biocompatibility and exerts its photothermal effect in vitro. Antitumor tests in mice demonstrated the capacity of DF-PEG-PAHy/BPNSs hydrogel for synergistic chemo-photothermal therapy in vivo. The hydrogel showed reduced adverse effects because of stable drug release in the tumor area and an efficient photothermal effect. Together, these data demonstrated the potential of DF-PEG-PAHy/BPNSs hydrogel containing a chemotherapy drug to serve as a novel smart delivery system for combined chemo-photothermal cancer therapy.
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