Quantitative zeptomolar imaging of miRNA cancer markers with nanoparticle assemblies

Significance Engineering of reconfigurable nanoparticle assemblies enabled the practical realization of multiplexed detection, monitoring, and in vivo imaging of miRNA in live cells and animals, which was previously impeded by the fast degradation of these essential epigenetic markers. Nanoparticle superstructures afford rapid quantitative assessment of the imaging results, facilitating proliferation of digital personalized medicine.