A Straightforward Route to Indolizidine and Quinolizidine Analogs as new Potential Antidiabetics

New polyhydroxylated indolizidine and quinolizidine analogs of castanospermine are efficiently obtained by a double reductive amination of enantiopure cyclic ketoaldehydes. As rigidi­fied mimics of disaccharides, these compounds are expected to exhibit significant antidiabetic properties.