The effect of simultaneous vitamin C and levothyroxine consumption on thyroid function of patients with primary hypothyroidism.

Abstract Introduction: Vitamin C is one of the life necessary soluble vitamins of body composition that its role has been shown in collagen synthesis, immunity, cancer prevention and a lots of enzyme activity. Thyroid function effects of vitamin C supplementation has proposed in some human and experimental studies. The aim of present study was to evaluate the effect of simultaneous consumption of vitamin C and levothyroxine on thyroid function of patients with primary hypothyroidism. Subjects and Methods: In this before-after clinical trial, 73 patients with primary hypothyroidism of both sexes were treated with one brand of levothyroxine sodium (OSVEH Company). Fasting serum levels of T3, T4, and TSH were measured before and 8 weeks after treatment. Then, vitamin C tablet 500mg was added to levothyroxine treatment of the same patients for another 8 weeks. Again, thyroid function was measured at the end of  this period. The results considered significant if P value was â�¤ 0.05. Results: With vitamin C, the mean levothyroxine need reduced in 83.6 percent of patients. (P=0.001). The results of present study showed significant difference between mean TSH levels, before and after adding vitamin C. (P=0.001) Conclusion: Consumption of Vitamin C with levothyroxine, improves primary hypothyroidism control.Â