心力衰竭
背景(考古学)
心肌炎
免疫系统
心肌病
炎症
射血分数
心肌梗塞
疾病
缺血性心肌病
医学
生物信息学
神经科学
心脏病学
生物
内科学
免疫学
古生物学
作者
Laura M. Wienecke,Jamison Leid,Florian Leuschner,Kory J. Lavine
出处
期刊:Circulation-cardiovascular Imaging
[Ovid Technologies (Wolters Kluwer)]
日期:2023-01-01
卷期号:16 (1)
被引量:5
标识
DOI:10.1161/circimaging.122.014071
摘要
Heart failure involves a complex interplay between diverse populations of immune cells that dynamically shift across the natural history of disease. Within this context, the character of the immune response is a key determinant of clinical outcomes. Recent technological advances in single-cell transcriptomic, spatial, and proteomic technologies have fueled an explosion of new and clinically relevant insights into distinct immune cell populations that reside within the diseased heart including potential targets for molecular imaging and therapy. In this review, we will discuss the immune cell types and their respective functions with respect to myocardial infarction remodeling, dilated cardiomyopathy, and heart failure with preserved ejection fraction. In addition, we give a brief overview regarding myocarditis and cardiac sarcoidosis as inflammatory heart failure etiologies. We will highlight markers and cell populations as targets for molecular imaging to visualize inflammation and tissue healing and discuss clinical implications including the development and implementation of precision medicine approaches.
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