雷达50
DNA
核酸外切酶
同源重组
生物
DNA修复
遗传学
DNA钳
核酸酶
计算生物学
细胞生物学
DNA结合蛋白
基因
DNA聚合酶
转录因子
逆转录酶
核糖核酸
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2023-03-09
卷期号:51 (2): 527-538
被引量:6
摘要
The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of life. It is an intricate DNA associated molecular machine that cuts, among other functions, a large variety of free and obstructed DNA termini for DNA repair by end joining or homologous recombination, yet leaves undamaged DNA intact. Recent years have brought progress in both the structural and functional analyses of Mre11–Rad50 orthologs, revealing mechanisms of DNA end recognition, endo/exonuclease activities, nuclease regulation and DNA scaffolding. Here, I review our current understanding and recent progress on the functional architecture Mre11–Rad50 and how this chromosome associated coiled-coil ABC ATPase acts as DNA topology specific endo-/exonuclease.
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