医学
胰腺炎
内镜逆行胰胆管造影术
肝移植
胃肠病学
内科学
并发症
奥迪括约肌功能障碍
腹痛
外科
移植
作者
Ahmed Shehta,Mohamed M. Elshobari,Tarek Salah,Ahmed Sultan,Amr Yasen,Mohamed Elsadany,Waleed Rifat Elsarraf,A. Abdel-Khalek,Usama Shiha,Gamal El Ebidy,Mohamed Abdel Wahab,Mohamed Elsaadany
标识
DOI:10.1097/meg.0000000000002521
摘要
Objectives Endoscopic retrograde cholangiopancreatography (ERCP) has shown great safety and efficacy in the management of post-living-donor liver transplantation (LDLT) biliary complications. Pancreatitis is the most commonest and the most feared complication after ERCP. Methods We reviewed the data of liver transplant recipients who underwent ERCP for biliary complications after LDLT between 2011 and 2022. Results In total 63 patients underwent ERCP after LDLT. They were targeted to 134 set of ERCP. Pancreatitis occurred in 52 sets (38.8%). We subclassified the patients into two groups, without pancreatitis: 31 patients (49.2%) and with pancreatitis 32 patients (50.8%). A higher incidence of pancreatitis was noticed with the first ERCP set ( P = 0.04). Biliary strictures were more noted in the pancreatitis group ( P = 0.025). Difficult cannulation requiring precut was more observed in the pancreatitis group ( P = 0.007). Also, more frequent sphincterotomy was observed in the pancreatitis group ( P = 0.003). Longer hospital stay, more fever, abdominal pain and vomiting were noted in the pancreatitis group ( P = 0.001). Higher post-ERCP serum amylase ( P = 0.001) and creatinine ( P = 0.021), while lower serum calcium ( P = 0.21) were noticed in the pancreatitis group. On multivariate analysis, preoperative diabetes, number of biliary anastomoses (single/multiple) and difficult cannulation requiring precut were significant predictors of post-ERCP pancreatitis. Conclusion Patient-related risk factors and bedside procedure-related risk factors play an essential role in the development of pancreatitis after ERCP for LDLT recipients. Endoscopists should be mindful by those high-risk patients during ERCP to apply appropriate techniques to prevent the development of this serious complication.
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