星形胶质细胞
神经科学
生物
血脑屏障
功能(生物学)
细胞器
受体
中枢神经系统
细胞生物学
生物化学
作者
Blanca Díaz-Castro,Stefanie Robel,Anusha Mishra
出处
期刊:Annual Review of Neuroscience
[Annual Reviews]
日期:2023-07-10
卷期号:46 (1): 101-121
被引量:37
标识
DOI:10.1146/annurev-neuro-091922-031205
摘要
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood flow, nutrient uptake, and waste clearance. Accordingly, astrocyte endfeet contain specialized organelles and proteins, including local protein translation machinery and highly organized scaffold proteins, which anchor channels, transporters, receptors, and enzymes critical for astrocyte-vascular interactions. Many neurological diseases are characterized by the loss of polarization of specific endfoot proteins, vascular dysregulation, BBB disruption, altered waste clearance, or, in extreme cases, loss of endfoot coverage. A role for astrocyte endfeet has been demonstrated or postulated in many of these conditions. This review provides an overview of the development, composition, function, and pathological changes of astrocyte endfeet and highlights the gaps in our knowledge that future research should address.
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