PEG比率
体内
纳米颗粒
体外
纳米医学
炎症
生物利用度
癌症研究
化学
免疫系统
肿瘤微环境
药理学
材料科学
纳米技术
肿瘤细胞
生物化学
免疫学
医学
生物
财务
生物技术
经济
作者
Nahar Jannatun,Yuqian Zhang,Ben Wu,Qingle Song,Guoli Cao,Wenhe Luo,Feng Yuan,Qi Li,Yanqiao Zeng,Guofang Zhang,Guocheng Wang,Y. Li
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2023-03-03
卷期号:6 (6): 4379-4389
被引量:7
标识
DOI:10.1021/acsanm.2c05472
摘要
Epigallocatechin-3-gallate (EGCG), the most abundant tea polyphenol, possesses excellent anti-inflammation properties. Emerging studies proved its potent potential as an immune checkpoint (ICP) inhibitor for anticancer therapy. However, the low bioavailability of EGCG reduces its treatment efficiency. In this work EGCG-based nanomedicine EGCG–ZIF-8@PDA–PEG (EZP) was developed via the coordination between ZIF-8 MOF and EGCG, followed by polydopamine and PEG functionalization for efficient tumor-targeting EGCG delivery. Results demonstrated that the EGCG loading rate in EZP reached up to 85%. Both in vitro and in vivo studies proved that the EZP nanoparticles were capable of inhibiting the expression of ICP molecules and modulating the inflammatory tumor microenvironment, evidenced by the suppression of PD-L1 expression, the reduction of inflammatory cytokines, and the resultant decline in the number of immunosuppressive cells, for instance, myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells. These synergistic effects significantly improved the infiltration of dendritic cells and T cells in tumors, realizing an inspiring antitumor effect.
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