化学
区域选择性
化学选择性
试剂
磺酰
硫化
硫黄
功能群
氰化物
组合化学
砜
金属
表面改性
基质(水族馆)
有机化学
催化作用
聚合物
物理化学
地质学
海洋学
烷基
作者
Nian Zheng,Wei‐Yu Shi,Yanan Ding,Xue-Yuan Liu,Yong‐Min Liang
标识
DOI:10.1002/adsc.202200975
摘要
Controllable chemoselectivity and regioselectivity synthesis of 3-sulfinylated, 3-sulfenylated and 2-sulfonylated indoles via direct C-H functionalization are realized under metal-free conditions. In particular, the synthesis of 3-arylsulfinylindoles in high yields from a sulfone substrate in water without additives is reported. The process displays excellent functional groups compatibility. p-Toluenesulfonyl cyanide (TsCN) possess a hexavalent sulfonyl group, as an odorless and easy-to-handle solid, which has been used as a new sulfur reagent through the cleavage of S-C and S=O bonds in our work.
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