转移
癌症
乳腺癌
癌症研究
CA15-3号
循环肿瘤细胞
紫杉醇
三阴性乳腺癌
化疗
癌细胞
医学
转移性乳腺癌
肿瘤科
生物
免疫学
内科学
作者
Nicola Aceto,Ana Gvozdenovic
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-07-07
卷期号:83 (17): 2811-2812
标识
DOI:10.1158/0008-5472.can-23-1978
摘要
Abstract Therapy resistance is frequently observed in cancer patients with distant metastases and effective management of metastatic disease remains challenging. Unraveling the cellular mechanisms and molecular targets fueling metastatic spread is crucial for advancing cancer therapies. In a recent issue of Cancer Discovery, Dashzeveg and colleagues revealed that loss of terminal sialylation in glycoproteins within circulating tumor cell clusters is a dynamic process that contributes to cellular dormancy, facilitates evasion of chemotherapy, and enhances metastatic seeding. Furthermore, the study identifies the glycoprotein podocalyxin (PODXL) as a potential target for counteracting the metastasis of quiescent tumor cells associated with paclitaxel treatment in triple-negative breast cancer.
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