核受体
孤儿受体
维甲酸
维甲酸受体
RAR相关孤儿受体γ
生物
受体
视黄醇X受体α
视黄醇X受体γ
内分泌学
癌症研究
医学
内科学
遗传学
转录因子
基因
作者
Felix Yemanyi,Kiran Bora,Alexandra K. Blomfield,Jing Chen
标识
DOI:10.1007/978-3-031-27681-1_47
摘要
The retinoic acid receptor-related orphan receptors (RORs) are ligand-mediated transcription factors with important biological roles in regulating circadian rhythms, metabolism, immunity, angiogenesis, inflammation, and development. They belong to the superfamily of nuclear receptors and include three family members: RORα, RORβ, and RORγ. Currently identified ROR ligands include cholesterol and cholesterol derivatives for RORα and RORγ, and stearic acid and all-trans retinoic acid for RORβ. Aberrant signaling of the RORs is involved in the pathogenesis of several human diseases including autoimmune diseases, metabolic disorders, and certain cancers. In the eye, RORs regulate normal development of the lens and the retina, and also contribute to potentially blinding eye diseases, especially retinal vascular diseases. Here, we review the role of RORs in eye development and disease to highlight their potential as druggable targets for therapeutic development in retinal vascular and degenerative diseases.
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