Undirected biocatalytic amination of unactivated C(sp3)−H bonds

Selective catalytic functionalization of C(sp3)−H bonds represents a powerful means to access valuable products from ubiquitous starting materials. In a recent Journal of the American Chemical Society paper, Arnold and co-workers engineered P450 nitrene transferases to aminate unactivated C(sp3)−H bonds with excellent site- and stereoselectivities.