胞质分裂
细胞分裂
S层
嗜酸热硫化叶菌
膜
细胞
古细菌
细胞生物学
生物物理学
纳米技术
格子(音乐)
细胞膜
材料科学
化学
生物
物理
生物化学
基因
声学
作者
Sherman Foo,Ido Caspy,Alice Cezanne,Tanmay A. M. Bharat,Buzz Baum
标识
DOI:10.1073/pnas.2501044122
摘要
The surface layer or “S-layer” is a two-dimensional lattice of proteins that coats a wide range of archaea and bacteria in place of a cell wall or capsular polysaccharides. S-layers are thought to play an important role in chemically and physically insulating cells from the external environment. Here, we show that the integrity of the S-layer in Sulfolobus acidocaldarius is maintained as cells grow via a process of self-assembly as SlaA monomers fill gaps in the lattice. Although this lattice which is physically tethered to the membrane might be expected to hinder cell division, we show that the S-layer flattens the membrane at cytokinesis to accelerate ESCRT-III-dependent cell division—and is important for robust, successful cell divisions under conditions of mechanical stress. Taken together, these results define the rules governing S-layer self-assembly and show how a flexible lattice coat that is coupled to the underlying membrane can both provide a cell with mechanical support and help to drive rapid and functionally important changes in cell shape.
科研通智能强力驱动
Strongly Powered by AbleSci AI