A Comparative Analysis of Glycemic Metrics Derived From Three Continuous Glucose Monitoring Systems

OBJECTIVE This study analyzed the differences in continuous glucose monitoring (CGM)-derived metrics among three current-generation systems and evaluated their impact on therapeutic decision-making. RESEARCH DESIGN AND METHODS Twenty-three participants wore the FreeStyle Libre 3, Dexcom G7, and Medtronic Simplera CGM systems for 14 days in parallel. CGM metrics were calculated for each participant and CGM system separately. RESULTS The apparent glucose profile was influenced by the used CGM system, resulting in substantially different glycemic metrics among the three systems. Agreement between FreeStyle Libre 3 and Dexcom G7 was higher than with Medtronic Simplera, which showed lower glucose levels, on average. There were marked intraparticipant discrepancies that would have resulted in different therapeutic recommendations. CONCLUSIONS The CGM systems indicated discordant glycemic metrics, which should be considered in diabetes therapy. Different CGM systems should provide the same glucose readings and CGM-derived metrics when used by the same person.