化学
酰肼
配体(生物化学)
催化作用
部分
铱
试剂
药物化学
烷基
甲醇
有机化学
生物化学
受体
作者
Wan‐Hui Wang,Wei-Yu Shao,Jia-Yue Sang,Xu Li,Xiaoqiang Yu,Yoshinori Yamamoto,Ming Bao
出处
期刊:Organometallics
[American Chemical Society]
日期:2023-04-01
卷期号:42 (18): 2623-2631
被引量:2
标识
DOI:10.1021/acs.organomet.3c00026
摘要
Direct N,N-dialkylation of acyl hydrazide catalyzed by a series of amidato iridium complexes bearing an electron-donating group in the ligand using methanol or ethanol as the alkyl reagent under weak base conditions (10 mol % KHCO3) is described. A wide range of acyl hydrazide derivatives are converted to the corresponding N,N-dialkylated products in excellent yields (38 examples, yields of ≤96%). On the basis of the control experiments and nuclear magnetic resonance studies, a plausible mechanism was proposed. The experimental results indicate that ortho electron-donating groups on the phenyl moiety of the picolinamide ligand play a crucial role in catalytic activity.
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