严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019年冠状病毒病(COVID-19)
气体分析呼吸
光谱学
大流行
冠状病毒
病毒学
医学
材料科学
化学
疾病
病理
色谱法
物理
传染病(医学专业)
量子力学
作者
Qizhong Liang,Ya-Chu Chan,Jutta Toscano,Kristen K. Bjorkman,Leslie A. Leinwand,Roy Parker,Eva S. Nozik,David J. Nesbitt,Jun Ye
出处
期刊:Journal of Breath Research
[IOP Publishing]
日期:2023-04-05
卷期号:17 (3): 036001-036001
被引量:4
标识
DOI:10.1088/1752-7163/acc6e4
摘要
Abstract Rapid testing is essential to fighting pandemics such as coronavirus disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exhaled human breath contains multiple volatile molecules providing powerful potential for non-invasive diagnosis of diverse medical conditions. We investigated breath detection of SARS-CoV-2 infection using cavity-enhanced direct frequency comb spectroscopy (CE-DFCS), a state-of-the-art laser spectroscopic technique capable of a real-time massive collection of broadband molecular absorption features at ro-vibrational quantum state resolution and at parts-per-trillion volume detection sensitivity. Using a total of 170 individual breath samples (83 positive and 87 negative with SARS-CoV-2 based on reverse transcription polymerase chain reaction tests), we report excellent discrimination capability for SARS-CoV-2 infection with an area under the receiver-operating-characteristics curve of 0.849(4). Our results support the development of CE-DFCS as an alternative, rapid, non-invasive test for COVID-19 and highlight its remarkable potential for optical diagnoses of diverse biological conditions and disease states.
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