重编程
MEF2C公司
表观遗传学
心力衰竭
诱导多能干细胞
疾病
生物
转录因子
生物信息学
医学
细胞
胚胎干细胞
心脏病学
内科学
遗传学
基因
作者
Glynnis A. Garry,Eric N. Olson
标识
DOI:10.1016/j.yjmcc.2023.03.013
摘要
Direct reprogramming of resident cardiac fibroblasts to induced cardiomyocytes is an attractive therapeutic strategy to restore function and remuscularize the injured heart. The cardiac transcription factors Gata4, Mef2c, and Tbx5 have been the mainstay of direct cardiac reprogramming strategies for the past decade. Yet, recent discoveries have identified alternative epigenetic factors capable of reprogramming human cells in the absence of these canonical factors. Further, single-cell genomics evaluating cellular maturation and epigenetics in the setting of injury and heart failure models following reprogramming have continued to inform the mechanistic underpinnings of this process and point toward future areas of discovery for the field. These discoveries and others covered in this review have provided complementary approaches that further enhance the effectiveness of reprogramming as a means of promoting cardiac regeneration following myocardial infarction and heart failure.
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