光学相干层析成像
医学
接收机工作特性
人工智能
眼底摄影
荟萃分析
糖尿病性黄斑水肿
人口统计学的
眼科
机器学习
验光服务
糖尿病性视网膜病变
糖尿病
内科学
计算机科学
视力
内分泌学
社会学
人口学
荧光血管造影
作者
C. S. Lam,Yiu Lun Wong,Zhangjun Tang,Xiaoyan Hu,Truong X. Nguyen,Dawei Yang,Siyuan Zhang,Jennifer Ding,Simon Szeto,An Ran Ran,Carol Y. Cheung
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2024-01-19
卷期号:47 (2): 304-319
摘要
BACKGROUND Diabetic macular edema (DME) is the leading cause of vision loss in people with diabetes. Application of artificial intelligence (AI) in interpreting fundus photography (FP) and optical coherence tomography (OCT) images allows prompt detection and intervention. PURPOSE To evaluate the performance of AI in detecting DME from FP or OCT images and identify potential factors affecting model performances. DATA SOURCES We searched seven electronic libraries up to 12 February 2023. STUDY SELECTION We included studies using AI to detect DME from FP or OCT images. DATA EXTRACTION We extracted study characteristics and performance parameters. DATA SYNTHESIS Fifty-three studies were included in the meta-analysis. FP-based algorithms of 25 studies yielded pooled area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity of 0.964, 92.6%, and 91.1%, respectively. OCT-based algorithms of 28 studies yielded pooled AUROC, sensitivity, and specificity of 0.985, 95.9%, and 97.9%, respectively. Potential factors improving model performance included deep learning techniques, larger size, and more diversity in training data sets. Models demonstrated better performance when validated internally than externally, and those trained with multiple data sets showed better results upon external validation. LIMITATIONS Analyses were limited by unstandardized algorithm outcomes and insufficient data in patient demographics, OCT volumetric scans, and external validation. CONCLUSIONS This meta-analysis demonstrates satisfactory performance of AI in detecting DME from FP or OCT images. External validation is warranted for future studies to evaluate model generalizability. Further investigations may estimate optimal sample size, effect of class balance, patient demographics, and additional benefits of OCT volumetric scans.
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