肾病
免疫学
配体(生物化学)
生物
医学
癌症研究
化学
计算生物学
受体
生物化学
糖尿病
内分泌学
标识
DOI:10.1080/14712598.2024.2346111
摘要
Introduction Immunoglobulin A (IgA) nephropathy is a common immune-mediated kidney disease leading to high blood pressure and may progress to kidney failure. None of the present treatments are disease-modifying or prolong life. The levels of A Proliferation Inducing Ligand (APRIL) are raised in subjects with IgA nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to, and neutralizes, APRIL.
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