孟德尔随机化
慢性阻塞性肺病
医学
骨质疏松症
内科学
优势比
单核苷酸多态性
出版偏见
肿瘤科
遗传变异
遗传学
生物
基因型
基因
作者
Zhangqi Dou,Xinru Chen,Jun Chen,Hua Ye,Jiaqi Chen
出处
期刊:Chronic obstructive pulmonary diseases
[COPD Foundation]
日期:2024-01-01
被引量:1
标识
DOI:10.15326/jcopdf.2024.0501
摘要
Background:The incidence of chronic obstructive pulmonary disease (COPD) and osteoporosis are rising worldwide.Observational studies showed that COPD is associated with increased risk of osteoporosis.We performed the Mendelian randomization (MR) study to genetically investigate the causality of COPD on osteoporosis. Methods:We explored the causal effect of COPD on osteoporosis by the MR analysis.A total of 108 genetic loci single nucleotide polymorphisms were related to COPD.The primary approach in this MR analysis was the inverse variance-weighted (IVW) method.Simple median, weighted median, MR Egger and penalized weighted median analyzed the sensitivity. Results:The study found that genetically predicted COPD is causally linked to an increased risk of osteoporosis, as evidenced by both the fixed-effect IVW model and random-effect IVW model (odds ratio [OR], 1.010; 95% CI, 1.001-1.019,P=0.021; OR, 1.010; 95% CI, 1.001-1.020,P=0.039).This association was also observed in other methods, including the simple median, weighted median, Penalised weighted median, MR-Egger method, and MR Egger (bootstrap) method.The results of the IVW and MR-Egger analyses showed no heterogeneity (Q=131.374,P=0.061 and Q=128.895,P=0.069, respectively).Additionally, MR-Egger regression did not reveal any pleiotropic influence through genetic variants (intercept, -0.004; P=0.101).Lastly, the leave-one-out sensitivity analysis did not identify any individual SNP that significantly influenced the association between COPD and osteoporosis. Conclusion:The Mendelian randomization analysis showed a significant detrimental effect of COPD on the risk of osteoporosis.
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