马尔科夫尼科夫法则
化学
烯烃
催化作用
钌
电泳剂
腙
组合化学
药物化学
立体化学
有机化学
区域选择性
作者
Siyi Luo,Hanh D. M. Pham,Chen‐Chen Li,Zihang Qiu,Ruofei Cheng,Rustam Z. Khaliullin,Chao‐Jun Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-04-04
卷期号:26 (15): 3004-3009
标识
DOI:10.1021/acs.orglett.4c00610
摘要
A well-defined Ru(II)-PNP complex demonstrated high activity in the anti-Markovnikov hydroalkylation of nonpolarized terminal alkenes via hydrazones. Hydrazone served as a carbanion equivalent to combine with the electrophilic alkene substrate upon activation by the ruthenium catalyst, forming a new C-C bond in a concerted pathway with N2 as the only theoretical byproduct. Experimental and computational studies suggested the existence of a push-pull interaction that activated the alkene for hydrazone addition and then deduced the mechanism.
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