Arrhythmic mitral annular disjunction syndrome: An underestimated cause of sudden cardiac death

Mitral valve disease is a common cause of heart failure and death. In the current issue of the Journal, Hasin et al. investigated the pathogenesis of functional mitral regurgitation and found that the reduced left ventricle (LV) rotational movement was independently associated with mitral regurgitation severity [1]. This case report has inspired us to investigate mitral annular disjunction (MAD), a syndrome often being misdiagnosed as functional mitral regurgitation at its early stage, and its role in sudden cardiac death (SCD), which has been ignored and underestimated in clinics.