催化作用
过氧化物酶
超氧化物
肿瘤微环境
催化效率
化学
基质(水族馆)
试剂
纳米片
酶
癌症治疗
组合化学
生物物理学
肿瘤细胞
生物化学
癌症
癌症研究
生物
有机化学
生态学
遗传学
作者
Jian Yang,Le Fang,Ruibin Jiang,Lubin Qi,Yong Xiao,Wenxi Wang,Ismail Ismailc,Xiaohong Fang
标识
DOI:10.1002/adhm.202300490
摘要
Abstract Nanoenzymes have been widely explored for chemodynamic therapy (CDT) in cancer treatment. However, poor catalytic efficiency of nanoenzymes, especially in the tumor microenvironment with insufficient H 2 O 2 and mild acidity, limits the effect of CDT. Herein, a new ultrathin RuCu nanosheet (NS) based nanoenzyme which has a large specific surface area and abundant channels and defects is developed. The RuCu NSs show superb catalytic efficiency for the oxidation of peroxidase substrate H 2 O 2 at a wide range of pH and their catalytic efficiency ( k cat / K m = 177.2 m −1 s −1 ) is about 14.9 times higher than that of the single‐atom catalyst FeN 3 P. Besides being an efficient nanozyme as peroxidase, the RuCu NSs possess other two enzyme activities, not only disproportionating superoxide anion to produce H 2 O 2 but also consuming glutathione to keep a high concentration of H 2 O 2 in the tumor microenvironment for Fenton reaction. With these advantages, the RuCu NSs exhibit good performance to kill cancer cells and inhibit tumor growth in mice, demonstrating a promising potential as new CDT reagent.
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