Exosome-Infused DTM-MPs Hydrogel Scaffold: A Smart Platform for Tendon Repair with Sustained Bioactivity and Anti-Inflammatory Benefits

evaluations in a rat Achilles tendon defect model confirmed that the DTM-MPs/CBD@sub-Exos/Gel scaffold accelerated tendon regeneration, restored mechanical properties, and exhibited sustained exosome release. Histological analysis revealed improved tendon matrix formation, with enhanced collagen synthesis and structural alignment in the CBD@sub-Exos-modified scaffold group. These findings suggest that the DTM-MPs/CBD@sub-Exos/Gel scaffold offers a promising therapeutic strategy for tendon injury repair by promoting tissue regeneration, modulating inflammation, and enhancing tissue repair outcomes.