免疫疗法
肿瘤微环境
免疫系统
细胞因子
癌症研究
免疫学
生物
免疫
医学
作者
Lindsay K. Dickerson,Jason A. Carter,Karan Kohli,Venu G. Pillarisetty
出处
期刊:Gut
[BMJ]
日期:2023-05-31
卷期号:72 (8): 1592-1606
被引量:1
标识
DOI:10.1136/gutjnl-2023-329650
摘要
The effectiveness of antitumour immunity is dependent on intricate cytokine networks. Interleukins (ILs) are important mediators of complex interactions within the tumour microenvironment, including regulation of tumour-infiltrating lymphocyte proliferation, differentiation, migration and activation. Our evolving and increasingly nuanced understanding of the cell type-specific and heterogeneous effects of IL signalling has presented unique opportunities to fine-tune elaborate IL networks and engineer new targeted immunotherapeutics. In this review, we provide a primer for clinicians on the challenges and potential of IL-based treatment. We specifically detail the roles of IL-2, IL-10, IL-12 and IL-15 in shaping the tumour-immune landscape of gastrointestinal malignancies, paying particular attention to promising preclinical findings, early-stage clinical research and innovative therapeutic approaches that may properly place ILs to the forefront of immunotherapy regimens.
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