C5L2 gene polymorphisms and their functional interaction with metabolic-inflammatory networks in T2DM-associated CHD: insights from an integrative genetic and clinical analysis in a Chinese population

C5L2 polymorphisms, particularly rs2972607, are modest but consistent contributors to T2DM-associated CHD and integrate with lipid, platelet, and inflammatory markers, highlighting a potential role in immune-metabolic interplay. While our findings are observational and hypothesis-generating, they are biologically plausible and align with established C5L2 biology, suggesting that integrating C5L2 genotyping with biochemical profiling may refine individualized risk prediction and guide future mechanistic studies.