Effect of Moro orange juice extract supplementation in weight management in adults: A systematic review and meta-analysis

Background and purpose Overweight and obesity are critical public health issues linked to chronic diseases such as type 2 diabetes and cardiovascular conditions. Moro orange juice extract has emerged as an alternative for promoting weight loss and improving body composition among overweight adults. Therefore, we conducted a systematic review and meta-analysis to evaluate its effectiveness and potential role in obesity management. Aim To evaluate the effectiveness of Moro orange juice extract supplementation on weight-related outcomes in overweight and obese adults. Methods We systematically searched PubMed, Embase, and Cochrane for randomized controlled trials (RCTs) comparing Moro orange juice extract with placebo in overweight adults. Our primary outcomes were changes in body weight and body mass index (BMI). Secondary outcomes included waist circumference, fat mass, and lean mass. Results Three RCTs involving 252 participants were included in our analysis. The extract significantly reduced body weight (mean difference (MD) −2.08 kg; 95% confidence interval (CI) −3.50, −0.67; I 2 = 0%; p < 0.01) and fat mass (MD −1.53 kg; 95% CI −2.92, −0.15; I 2 = 0%; p = 0.03), the pooled analysis of waist circumference presented heterogeneous point estimates (MD −3.25 kg; 95% CI −6.44, −0.07; I 2 = 99%; p = 0.05). No significant effects were observed on lean mass. Conclusion Moro orange juice extract may result in weight and fat mass reduction in overweight and obese adults. However, additional research is needed to determine the optimal dosage, duration of supplementation, and underlying mechanisms.