荧光
材料科学
药物输送
兴奋剂
量子点
锌
纳米技术
体内
吸收(声学)
量子产额
药品
光电子学
药理学
医学
物理
生物技术
量子力学
冶金
复合材料
生物
作者
Ruixin Hao,Shanshan Luo,Feiyan Wang,Xinyu Pan,Jianquan Yao,Jielian Wu,Haihong Fang,Wenkui Li
标识
DOI:10.3389/fchem.2022.1042038
摘要
ZnO quantum dots (QDs) have received much attention as biomarkers and drug delivery systems in cancer treatment, due to their low cost, ease of preparation, and pH-responsive degradation. However, its applications are limited by the low quantum yield and light absorption. In this work, a lanthanum-doped zinc oxide (La-ZnO) QDs-based drug delivery platform was constructed. The results show that 4% La doping is the most beneficial for improving the fluorescent properties of the ZnO QDs. After loading the drug, the cell activity was 15% at ZnO@DOX and 12% at La-ZnO@DOX. According to in vitro and in vivo experiment results, the La-ZnO QDs show enhancement of the antitumor effect. Dual enhancement of fluorescence and anti-tumor effects make La-ZnO QDs promising as a drug delivery system in cancer treatment.
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