Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury

HomeCirculation ResearchVol. 133, No. 7Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextCardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury James Rhee, Rebecca Freeman, Kangsan Roh, Margaret Lyons, Chunyang Xiao, Daniel Zlotoff, Ashish Yeri, Haobo Li, Justin Guerra, J. Sawalla Guseh, Alexandra Kuznetsov, Nicholas Houstis, Jason Roh, Federico Damilano, Xiaojun Liu, Michael Silverman, Raymond Kwong, Saumya Das and Anthony Rosenzweig James RheeJames Rhee Correspondence to: James Rhee, MD, PhD, Massachusetts General Hospital, Boston, MA, Email E-mail Address: [email protected] Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Department of Anesthesia, Critical Care, and Pain Medicine (J. Rhee, R.F., K.R., M.L.), Massachusetts General Hospital, Boston. Search for more papers by this author , Rebecca FreemanRebecca Freeman Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Department of Anesthesia, Critical Care, and Pain Medicine (J. Rhee, R.F., K.R., M.L.), Massachusetts General Hospital, Boston. Search for more papers by this author , Kangsan RohKangsan Roh https://orcid.org/0000-0001-8067-7772 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Department of Anesthesia, Critical Care, and Pain Medicine (J. Rhee, R.F., K.R., M.L.), Massachusetts General Hospital, Boston. Search for more papers by this author , Margaret LyonsMargaret Lyons Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Department of Anesthesia, Critical Care, and Pain Medicine (J. Rhee, R.F., K.R., M.L.), Massachusetts General Hospital, Boston. Search for more papers by this author , Chunyang XiaoChunyang Xiao https://orcid.org/0000-0003-1972-2241 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Daniel ZlotoffDaniel Zlotoff Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Ashish YeriAshish Yeri Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Haobo LiHaobo Li https://orcid.org/0000-0002-5660-7835 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Justin GuerraJustin Guerra https://orcid.org/0000-0001-8507-5922 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor (J.G., A.R.). Search for more papers by this author , J. Sawalla GusehJ. Sawalla Guseh https://orcid.org/0000-0003-0992-5635 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Alexandra KuznetsovAlexandra Kuznetsov https://orcid.org/0000-0002-6074-5819 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Nicholas HoustisNicholas Houstis Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Jason RohJason Roh https://orcid.org/0000-0002-6999-6868 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Federico DamilanoFederico Damilano Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Xiaojun LiuXiaojun Liu Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Michael SilvermanMichael Silverman https://orcid.org/0000-0002-5885-1866 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author , Raymond KwongRaymond Kwong https://orcid.org/0000-0001-8212-0759 Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA (R.K.). Search for more papers by this author , Saumya DasSaumya Das https://orcid.org/0000-0002-4521-4606 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Search for more papers by this author and Anthony RosenzweigAnthony Rosenzweig Anthony Rosenzweig, MD, University of Michigan Medical Center, Ann Arbor, MI, Email E-mail Address: [email protected] https://orcid.org/0000-0001-6387-0386 Department of Medicine, Cardiovascular Research Center and Division of Cardiology (J. Rhee, R.F., K.R., M.L., C.X., D.Z., A.Y., H.L., J.G., J.S.G., A.K., N.H., J. Roh, F.D., X.L., M.S., S.D., A.R.), Massachusetts General Hospital, Boston. Institute for Heart and Brain Health, University of Michigan Medical Center, Ann Arbor (J.G., A.R.). Search for more papers by this author Originally published28 Aug 2023https://doi.org/10.1161/CIRCRESAHA.123.322640Circulation Research. 2023;133:651–653FootnotesFor Sources of Funding and Disclosures, see page 653.Correspondence to: James Rhee, MD, PhD, Massachusetts General Hospital, Boston, MA, Email jrhee@partners.orgAnthony Rosenzweig, MD, University of Michigan Medical Center, Ann Arbor, MI, Email anthros@med.umich.eduREFERENCES1. Schachinger V, Assmus B, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Yu J, Corti R, Mathey DG, Hamm CW, et al; REPAIR-AMI investigators. Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial.Eur J Heart Fail. 2009; 11:973–979. doi: 10.1093/eurjhf/hfp113CrossrefMedlineGoogle Scholar2. 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