京尼平
甲壳素
自愈水凝胶
化学工程
壳聚糖
材料科学
高分子化学
化学
工程类
作者
Feier Chen,Ying Liu,Yujun Zou,Jueyi Zhu,Liang Liu,Yimin Fan
标识
DOI:10.1016/j.ijbiomac.2022.08.201
摘要
In this work, genipin crosslinked chitin nanofibril hydrogels/cryogels were successfully prepared. Due to the acidic disperse nature of positively charged chitin fibrils, the pH nature for the chemical crosslinking between chitin nanofibrils and genipin was restricted under 5.0. The pH nature and crosslinking temperature were found greatly influence the efficient chemical crosslinking between chitin nanofibril and genipin. Further ice templated crosslinking was found effective enhancing the mechanical properties of resulting chitin nanofibril hydrogels/cryogels. The cryogel prepared by genipin-crosslinked DEChNs showed interconnected pores, presenting a state of stacking layers. In addition, the deposition of hydroxyapatite (HA) on the surface of chitin nanofibril scaffolds was found effective for improving chondrocyte attachments and growths. The cells viability indicated the good cell compatibility of the cryogel. All the results indicated that the cryogel prepared by genipin-crosslinked DEChNs showed a potential for tissue engineering applications.
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