Manganese- and Iron-Catalyzed Carbonylation Reactions: A Personal Account

Abstract Transition-metal-catalyzed carbonylative transformations have been widely employed to convert CO gas into valuable carbonyl-containing molecules, mainly using noble metals (Pd, Rh, Ir, Ru) and more recently nickel and other catalysts. Although noble-metal catalysts have the advantage of reaction efficiency, their high-cost has led scientists to explore alternative procedures. Also under these backgrounds, we carried out some studies on nonexpensive metal-catalyzed carbonylative transformations. In this Account, we summarize the carbonylation reactions developed in our research group by using manganese and iron catalysis. These carbonylation reactions proceeded either via SET (single-electron transfer) or TET (two-electron transfer) mechanism. 1 Introduction 2 Manganese-Catalyzed Carbonylation of Alkyl Chlorides 3 Manganese-Catalyzed Carbonylation of Alkyl Iodides 4 Iron/Copper-Catalyzed Carbonylation of Alkyl Bromides 5 Iron-Catalyzed Carbonylation of Alkyl Bromides 6 Iron-Catalyzed Carbonylation of Alkyl-Boronic Pinacol 7 Iron-Catalyzed Aminoalkylative Carbonylative Cyclization of Alkenes 8 Conclusion and Outlook