Wnt信号通路
氧化应激
纤维化
阿特拉津
肾
活性氧
炎症
转化生长因子
生物累积
肾功能
毒性
内科学
内分泌学
化学
医学
生物
信号转导
生物化学
杀虫剂
有机化学
农学
作者
Taiwei Wang,Xuemiao Huang,Jian Liu,Wei Liu,Zhaoyun Yang,Kang He,Junyu Chen,Lijing Zhao
摘要
Exposure to atrazine (ATR), a widely-used herbicide, is a potential harmful to human health due to its long-term environmental persistence and bioaccumulation. The effects of chronic exposure to ATR on renal function in rats were evaluated in this research. Female Sprague-Dawley rats at 4 weeks of age were treated with different concentrations of ATR for 6 months. No significant differences in terms of renal functions were observed after ATR treatment. In histopathological examination of the kidney, Hematoxylin-Eosin staining indicated the development of degenerative changes in a dose-dependent manner. The results revealed that ATR exposure leads to renal fibrosis and that activation of the Wnt/β-catenin pathway plays a potential role in ATR-related renal fibrosis. Levels of transforming growth factor (TGF)-β and TGF-β1 levels and the reactive oxygen species were significantly upregulated after ATR treatment. In conclusion, long-term exposure to ATR could cause kidney fibrosis, which is the result of epithelial-mesenchymal transition caused by inflammation and oxidative stress.
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