化学
对映选择合成
硅烷化
结合
立体中心
基质(水族馆)
催化作用
有机化学
组合化学
数学分析
海洋学
数学
地质学
作者
Xiao Wang,Guo-Li Chai,Yajing Hou,Meijun Zhou,Junbiao Chang
标识
DOI:10.1021/acs.joc.3c00057
摘要
Herein, we report (R)-3,3'-(3,5-(CF3)2-C6H3)2-BINOL-catalyzed enantioselective conjugate addition of organic boronic acids to β-silyl-α,β-unsaturated ketones, furnishing moderate to excellent yields of the corresponding β-silyl carbonyl compounds with stereogenic centers in excellent enantioselectivities (up to 98% ee). Moreover, the catalytic system features mild reaction conditions, high efficiency, broad substrate scope, and easy scale-up.
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