Macrophage stimulation by angiopoietins-1 and -2 promotes recruitment and retention of white blood cells at sites of inflammation

The authors have previously found that macrophages are predominant targets of the angiogenic factors angiopoietin (Ang)-1 and -2 in synovial tissue of patients with rheumatoid arthritis (RA). How macrophage Tie2 ligation by Ang might contribute to disease in RA is currently …