First Identification of Flatbush Diabetes in Patients of Indian Origin

Ketosis-prone diabetes is an emerging heterogeneous syndrome that encompasses the biochemical, clinical, genetic, and pathophysiological features of diabetes. This allows for a more comprehensive stratification of the disease vis-a-vis the traditional type 1 diabetes and type 2 diabetes subdivision (1). Flatbush diabetes, a subset of ketosis-prone diabetes, was first described in African Americans. Following this, it has been characterized in Hispanic, Chinese, and Japanese cohorts (2,3). A thorough literature search using MEDLINE/PubMed and the Cochrane Library databases (MeSH terms: Indian, ketogenic diabetes, ketosis prone diabetes, and Flatbush diabetes mellitus) determined that Flatbush diabetes has never been described in patients of Indian origin. We identified a 39-year-old man who was admitted with mild diabetic ketoacidosis (based on his ketone status, serum …