遗传密码
氨基酸
转移RNA
氨酰tRNA合成酶
氨基酰基tRNA合成酶
大肠杆菌
计算生物学
酵母
生物
功能(生物学)
生物化学
遗传学
化学
核糖核酸
基因
作者
Chang C. Liu,Peter G. Schultz
标识
DOI:10.1146/annurev.biochem.052308.105824
摘要
The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of Escherichia coli, yeast, and mammalian cells. These UAAs represent a wide range of structures and functions not found in the canonical 20 amino acids and thus provide new opportunities to generate proteins with enhanced or novel properties and probes of protein structure and function.
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