Chitosan-Functionalized Magnetic Graphene Oxide Nanocomposites Enable High-Purity mRNA Enrichment To Avoid False Positives in LC-MS/MS Modification Profiling

-methylation) and specific oligonucleotide fragments was significantly reduced, substantially avoiding the risk of false-positive identifications. This novel platform established an effective sample preparation method for mRNA modification analysis, while its expandability to diverse downstream applications provides high-quality mRNA for empowering next-generation mRNA-based diagnostics and therapeutics.