Spatiotemporal Decoupling of Carbon and Energy Flux Enables Efficient Biomanufacturing of Aviation Fuel Precursors from CO 2

, corresponding to a 3-fold increase in product titer over conventional methanol-feeding strategies. By spatiotemporally decoupling carbon supply from energy regeneration, this work establishes a generalizable framework for solar-driven biosynthesis of complex multicarbon feedstocks and advances the development of a circular bioeconomy.