[Exploring multidimensional environmental exposure and strategies for the co-prevention of multimorbidity in children and adolescents].

.) collectively form a mixed exposure network. These factors affect the health of multiple systems, including respiratory, metabolic, and neurodevelopmental systems, of children and adolescents through biological mechanisms such as epigenetic programming, immune-metabolic disruption, microbiome dysbiosis, and neuro-immune-endocrine network interactions, resulting in multi-disease co-occurrence. In addition, this paper introduces the co-occurrence of multiple diseases in children and adolescents in the context of "common exposure-common mechanism-common prevention" and suggests targeted intervention strategies, including risk factor identification, exposure source control and novel multidimensional environment management, to provide scientific evidence for building a co-prevention system for multiple childhood diseases and informing precision public health practices.