OPTIMIZATION AND CHARACTERIZATION OF CHITOSAN-COATED LAMOTRIGINE NANOLIPOSOMES FOR EFFICIENT NOSE-TO-BRAIN DRUG DELIVERY

The traditional oral treatment of epilepsy has its limits due to the blood brain barrier and other variables that hinder the medications from reaching the brain properly. The aim of the study was to create, optimise and characterise chitosan-coated lamotrigine nanoliposomes for effective intranasal nasal to brain drug delivery. Liposomes were prepared by thin film hydration technique and probe sonication. The amounts of phospholipids, cholesterol, chitosan and sonication time were systematically varied to generate 152 formulation batches. Physical stability, entrapment efficiency