The CALLY index in cancer research: a comprehensive review

This review focuses on the CALLY index in cancer, exploring its theoretical foundations, epidemiological insights, diagnostic and prognostic applications, therapeutic implications, controversies, and future perspectives. The CALLY index, based on C - reactive protein, albumin, and lymphocyte levels, has shown potential in predicting cancer prognosis and guiding treatment. Multiple studies across various cancer types indicate its association with survival outcomes, yet its widespread clinical adoption faces challenges. By synthesizing current research, this review aims to provide a comprehensive understanding of the CALLY index, highlighting its strengths, limitations, and potential for advancing cancer management in precision medicine.