G‐Quadruplex‐Modular CpG Nanoplatform Drives Multi‐Pathway Immunity for Abscopal Chemoimmunotherapy

T cell infiltration, and reducing regulatory T cell accumulation. This cascade of immune modulation effectively reprograms the TME into an immune-permissive state. In murine 4T1 breast cancer models, IONP-G4-DOX/IMT achieves a primary tumor suppression rate of approximately 79.4%, with no significant systemic toxicity. More importantly, it elicits potent long-term antitumor immunity that inhibits contralateral tumor growth, offering a versatile and promising strategy for advanced abscopal chemoimmunotherapy.