蛋白酵素
蛋白酶
抗菌剂
微生物学
抗菌肽
牙龈卟啉单胞菌
生物
蛋白水解酶
细菌
蛋白质水解
化学
生物化学
酶
遗传学
作者
Bernard J. Moncla,Kara Pryke,Lisa C. Rohan,Phillip W. Graebing
出处
期刊:Advances in Bioscience and Biotechnology
[Scientific Research Publishing, Inc.]
日期:2011-01-01
卷期号:02 (06): 404-408
被引量:69
标识
DOI:10.4236/abb.2011.26059
摘要
We hypothesized that current antimicrobial peptides should be susceptible to proteolytic digestion. The antimicrobial peptides: Griffithinsin, RC-101, LL-37, LSA-5, PSC-RANTES and DJ007 were degraded by commercially available proteases. Two different species of anaerobic vaginal flora, Prevotella bivia and Porphyromonas asaccharolytica also degraded the materials. Griffithsin was resistant to digestion by 8 of the 9 proteases and the bacteria while LL-37 was the most sensitive to protease digestion. These data suggests most of the molecules may not survive for very long in the proteolytic rich environments in which they are intended to function.
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