化学
烯醇
非对映体
催化作用
硅烷化
芳基
结合
硅烯醇醚
有机化学
对映体
组合化学
数学
数学分析
烷基
作者
Junghyun Chae,Jaesook Yun,Stephen L. Buchwald
出处
期刊:Organic Letters
[American Chemical Society]
日期:2004-11-23
卷期号:6 (26): 4809-4812
被引量:90
摘要
Enantiomerically enriched β-substituted diphenylsilyl enol ethers, which can be prepared from Cu-catalyzed asymmetric conjugate reduction, are utilized in the Pd-catalyzed arylation of various aryl bromides. This new method provides a simple route to α-arylated cycloalkanones with excellent levels of enantiomeric and diastereomeric purity. The isolation of the intermediate, diphenylsilyl enol ethers is not necessary; the procedure can be carried out in one-pot.
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