脂质体
体内
医学
体内分布
体外
靶向治疗
癌症研究
生物物理学
癌症
生物化学
纳米技术
材料科学
化学
生物
内科学
生物技术
作者
Wei Li,Bo Su,Shuyan Meng,Liu Ju,Ling Yan,Yongmei Ding,Shanshan Yin,Wei Zhou,Heyan Li,Liang Tang,Yiqing Zhao,Caicun Zhou
标识
DOI:10.1016/j.ejrad.2011.01.051
摘要
Magnetic resonance molecular imaging has emerged as a potential approach for tumor diagnosis in the last few decades. This approach consists of the delivery of MR contrast agents to the tumor by specific targeted carriers. For this purpose, a lipopeptide was constructed by using a cyclic RGD peptide headgroup coupled to palmitic acid anchors via a KGG tripeptide spacer. Targeted paramagnetic liposomes were then prepared by the incorporation of RGD-coupled-lipopeptides into lipid bilayers for specific bounding to tumor. In vitro, study demonstrated that RGD-targeted liposomes exhibited a better binding affinity to targeted cells than non-targeted liposomes. MR imaging of mice bearing A549 tumors with the RGD-targeted paramagnetic liposomes also resulted in a greater signal enhancement of tumor compared to non-targeted liposomes and pure contrast agents groups. In addition, biodistribution study also showed specific tumor targeting of RGD-targeted paramagnetic liposomes in vivo. Therefore, RGD-targeted paramagnetic liposomes prepared in the present study may be a more promising method for early tumor diagnosis.
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