生长素
失眠症
内分泌学
下丘脑
焦虑
内科学
受体
医学
睡眠剥夺
萧条(经济学)
心理学
昼夜节律
精神科
宏观经济学
经济
作者
Liye Wang,Yuehan Song,Feng Li,Yan Liu,Jie Ma,Meng Mao,Fengzhi Wu,Ying Wu,Sinai Li,Binghe Guan,Xiaolan Liu
标识
DOI:10.4103/1673-5374.125351
摘要
Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model establishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors.
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