Recent advances in metal complexes and nanostructured materials for enhanced chemodynamic therapy

play central roles in catalyzing Fenton or Fenton-like reactions. Recent advances in inorganic and coordination chemistry have enabled the design of metal complexes with improved catalytic activity, selectivity, and stability. Furthermore, the development of nanostructured materials, such as metal-organic frameworks (MOFs), porous nanocarriers, and heterojunction nanoparticles, has expanded the possibilities for combining CDT with other therapies. These nanostructures not only serve as efficient carriers for metal complexes but also offer additional functionalities, including targeted drug release, TME modulation, and ROS amplification. This review comprehensively summarizes recent progress in the field, with a focus on mechanistic insights, design principles, and emerging translational opportunities for CDT-based combination therapies.