神经干细胞
自愈水凝胶
再生医学
干细胞
祖细胞
缺氧(环境)
肌红蛋白
神经科学
细胞
生物
细胞生物学
化学
氧气
生物化学
有机化学
作者
Yi Wang,E. R. Zoneff,Jacob Thomas,Nansook Hong,Li Lynn Tan,Duncan J. McGillivray,Adam W. Perriman,Kevin C. L. Law,Lachlan H. Thompson,Niamh Moriarty,Clare L. Parish,Richard J. Williams,Colin J. Jackson,David R. Nisbet
标识
DOI:10.1038/s41467-023-36133-8
摘要
Injectable biomimetic hydrogels have great potential for use in regenerative medicine as cellular delivery vectors. However, they can suffer from issues relating to hypoxia, including poor cell survival, differentiation, and functional integration owing to the lack of an established vascular network. Here we engineer a hybrid myoglobin:peptide hydrogel that can concomitantly deliver stem cells and oxygen to the brain to support engraftment until vascularisation can occur naturally. We show that this hybrid hydrogel can modulate cell fate specification within progenitor cell grafts, resulting in a significant increase in neuronal differentiation. We find that the addition of myoglobin to the hydrogel results in more extensive innervation within the host tissue from the grafted cells, which is essential for neuronal replacement strategies to ensure functional synaptic connectivity. This approach could result in greater functional integration of stem cell-derived grafts for the treatment of neural injuries and diseases affecting the central and peripheral nervous systems.
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